With a rogue villain from the Phantom Zone on the loose, Kara and James are stunned by the news that CatCo has an ambitious new owner. Meanwhile Kara determines to let Lena in on her secret identity, knowing it might forever undermine their relationship.
J'onn suffers from a Martian disorder after being attacked by someone claiming to be his brother, and turns to Kelly's Q wave technology for help. Kara struggles with her new boss's priorities, and Lena confronts Eve Teschmacher.
While Kara investigates the mysterious death of a young entrepreneur, J'onn turns to Nia and her powers to explore his suppressed memories. Lena turns to Supergirl after learning that some of Lex's secret journals are being held inside a government facility, while Kelly is approached by an old "friend" from her past.
A failed attempt to capture Malefic sends the D.E.O. team back to the drawing board, calling in Lena for help. Kelly and James take a trip back to their roots, and Kara discovers a connection between her colleague William Dey and organized crime.
As Andrea Rojas's VR contact lens project prepares for its public launch, Kara and William's investigations bring them together -- with a mecha-powered killer on the loose. Lena convinces Malefic to participate in her research.
A shadow warrior infiltrates the D.E.O., attempting to capture the high-powered prisoner Rip Roar. Meanwhile Andrea trusts Lena with a secret, dredging up old memories of their past friendship.
Leviathan's efforts to retrieve the medallion bring an ancient warrior out of hiding -- Rama Khan, who has the power to bend the earth to his will. While J'onn discovers the truth about his brother's fate, Supergirl takes Lena to the Fortress of Solitude.
With her relationship with Lena torn asunder, Supergirl is left with few options to prevent her psychic attack on the city. Meanwhile Rama Khan and his allies regroup with a new plan to retrieve the power of the medallion, and J'onn brings Malefic to the D.E.O.
As a crisis erupts across the multiverse, the Monitor gathers Supergirl, Green Arrow and his daughter Mia, Batwoman, White Canary and the Atom, the Flash and other heroes to make a stand on Earth-38 -- where a massive anti-matter wave threatens to consume Kara's Earth.
With the universe rewritten and Lex Luthor leading the D.E.O. Kara, Alex, and Lena must decide whether to move forward with their new reality. Brainiac faces his true self when multiple copies of himself show up on Earth, with a hidden enemy targeting them.
With a copycat Toyman on the loose and out for revenge, Winn Schott returns from the future to try and stop the man who is wearing his face -- and putting his own future at risk.
The D.E.O. is put on lockdown after a drone attack reveals that Winn's Toyman doppelganger problem isn't over yet. Brainy's alliance with Lex Luthor is tested, and Andrea hits a roadblock in the development of her upgrade of Obsidian.
The fifth-dimensional being Mxyzptlk returns with an offer to let Kara change her past and make things right with Lena. But the alternate histories could make the world as she knows it even worse.
After Andrea is attacked by an anti-tech extremist on the eve of the launch of her Obsidian Platinum VR system, Supergirl is assigned to be her personal bodyguard. Lena moves forward with her Non Nocere research -- using human test subjects inside a prison.
Nia decides to take matters into her own hands after her roommate, Yvette, is attacked by a man who wants to send Dreamer an anti-transgender message. Meanwhile Alex uses the experimental next-gen VR system to try and rescue a man trapped inside.
A grieving Alex uses Obsidian lenses to take on the role of Supergirl in the virtual reality world, where she finds that some of the human residents are beginning to lose their memories of their real identities.
In the days following Crisis, Lex Luthor lays out an intricate plan to pit Leviathan against Supergirl while making himself into a global hero -- no matter who he has to step on along the way.
Leviathan unleashes Rama Khan to retrieve a necessary component of its weapon against Supergirl, once again putting Brainy in a compromised position. As Alex searches for a lead on Leviathan's secret location, Lena and Lex find themselves amidst a prison riot after the Non Nocere passivism protocol fails.
Leviathan welcomes Lex Luthor into their inner sanctum, as the group plots to eliminate Supergirl once and for all. While her friends fight to protect her, Kara gets help from Lena -- and Brainy decides the only way to save the planet is to sacrifice himself.
