In the season premiere, Sarah is out of options, on the run, and pursued by deadly adversaries. Desperate to find her daughter Kira, Sarah suspects ruthless pro-clone Rachel is behind her daughter’s disappearance and sparks an all out war against her.  Alison and Donnie attend the funeral of her fallen friend, Aynsley, causing Alison to sink into guilt and despair.  Cosima is faced with a perplexing decision that may have dire consequences.

In the explosive return, Sarah is out of options, on the run, and being pursued by deadly adversaries. Desperate to find her daughter Kira (Skyler Wexler, ALPHAS), Sarah’s scorched earth tactics bring her face to face with the “pro-clone” Rachel. Meanwhile, with Alison’s carefully crafted suburban world spinning out of control, and the genetic illness affecting Cosima threatening them all, Sarah must negotiate a dangerous world of new enemies and shifting allegiances to get to the bottom of the experiment that made them who they are.