Season Two

Medusa

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CADMUS unleashes a deadly virus that targets aliens and leaves Mon-El in quarantine, prompting Kara to try and learn what Lena really knows about her mother. Meanwhile Alex struggles to reveal her truth when her mother visits for Thanksgiving, and a pair of visitors arrive from a parallel dimension.
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News & Spoilers

A NIGHT OF CONFESSIONS; THE EPIC SUPERHERO CROSSOVER KICKS OFF TONIGHT

Eliza (guest star Helen Slater) comes to town to celebrate Thanksgiving with her daughters. Alex (Chyler Leigh) decides it's time to come out to her mother; Kara (Melisa Benoist) is shocked when Eliza suggests Mon-El (Chris Wood) has feelings for her, and Winn (Jeremy Jordan) and James (Mehcad Brooks) consider telling Kara the truth about the Guardian. Meanwhile, CADMUS unleashes a virus that instantly kills any alien in the vicinity so Kara enlists an unexpected ally - Lena Luthor (Katie McGrath).

The epic superhero crossover kicks off tonight when Barry Allen (guest star Grant Gustin) and Cisco Ramon (guest star Carlos Valdes) seek Kara's help with an alien invasion on their Earth.

Stefan Pleszczynski directed the episode written by Jessica Queller & Derek Simon (#208).